LMAN1 antibody
GTX82190
Overview
- SupplierGeneTex
- Product NameLMAN1 antibody
- Delivery Days Customer10
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostChicken
- IsotypeIgY
- Scientific DescriptionMannose-specific lectin. May recognize sugar residues of glycoproteins. glycolipids. or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins. lipids. or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi. presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning. the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency. a rare. autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203