LRP4 Antibody

Catalog number: MBS7043923_0,05ml
Brand: MyBioSource
Packing: 0,05 ml
Other sizes: Other sizes available, please contact us.
Price: € 209.00
Expected delivery time: 21 days
Quantity:
Western Blot (WB)
Western blotAll lanes: LRP4 antibod...
Immunohistochemistry (IHC)
Immunohistochemistry of paraffin-em...

Product specifications for - LRP4 Antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Host: Rabbit
Target: LRP4
Target description: LDL receptor related protein 4
Clonality: Polyclonal
Isotype: IgG
Properties: 
Molecular weight: 212045 Da
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Liquid
Storage instructions: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Scientific information: 
Scientific info: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Gene ID: 4038
Swiss prot ID: O75096
Additional information: 
Synonyms: CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2; low-density lipoprotein receptor-related protein 4; multiple epidermal growth factor-like domains 7