MICA antibody [13M21]
GTX52926
ApplicationsWestern Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
TargetMICA
Overview
- SupplierGeneTex
- Product NameMICA antibody [13M21]
- Delivery Days Customer10
- ApplicationsWestern Blot, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID13M21
- Concentration500 ug/ml
- Gene ID100507436
- Target nameMICA
- Target descriptionMHC class I polypeptide-related sequence A
- Target synonymsHLA class I antigen; major histocompatibility complex class I chain-related protein A; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related chain A; MHC class I related sequence A; MIC-A; PERB11.1; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A; truncated MICA
- HostMouse
- IsotypeIgG
- Scientific DescriptionThis gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203