MLKL antibody

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Rohde K et al., 2017 Jan, Cell Death Differ

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression. Dai J et al., 2020 Apr 24, Cell Death Dis

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex. Seo J et al., 2020 Nov, Cell Death Differ

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex. Seo J et al., 2020 Nov, Cell Death Differ

CK1alpha, CK1delta, and CK1epsilon are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Hanna-Addams S et al., 2020 Jan 28, Proc Natl Acad Sci U S A

CK1delta as a potential therapeutic target to treat bladder cancer. Lin YC et al., 2020 Apr 13, Aging (Albany NY)

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Tonnus W et al., 2021 Jul 20, Nat Commun

Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation. Palmer SN et al., 2021 Dec 9, Mol Biol Evol

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Liu S et al., 2017 Sep 5, Proc Natl Acad Sci U S A

Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage. Aredia F et al., 2016 Nov 5, BMC Cancer