GTX627421 WB Image
GTX627421 WB Image
Nanog antibody [GT3312]
GTX627421
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameNanog antibody [GT3312]
- Delivery Days Customer9
- CertificationResearch Use Only
- Clone IDGT3312
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionTranscription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3 (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A simplified approach for derivation of induced pluripotent stem cells from Epstein-Barr virus immortalized B-lymphoblastoid cell lines. Walker SJ et al., 2021 Apr, HeliyonRead more
- CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1alpha/CXCR4 axis. Huang AF et al., 2013 Oct 5, Mol CancerRead more
- CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines. Biagioni A et al., 2021, Front OncolRead more
- Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells. Chen YL et al., 2021 Jan 12, Sci RepRead more
- ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line. Chen YL et al., 2019 Dec 24, Cancers (Basel)Read more
- From ACTH-Dependent to ACTH-Independent Cushings Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Ramirez-Renteria C et al., 2020, Case Rep EndocrinolRead more
- FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State. Blanas A et al., 2020 Sep 10, Cancers (Basel)Read more
- FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State. Blanas A et al., 2020 Sep 10, Cancers (Basel)Read more
- MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance. Ko CY et al., 2018 Apr, Mol NeurobiolRead more
- Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells. Chen YH et al., 2019 Jul 9, Sci RepRead more