GTX70224 WB Image
GTX70224 WB Image
NBS1 antibody [1D7] - KO/KD Validated
GTX70224
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameNBS1 antibody [1D7] - KO/KD Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1D7
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- 53BP1 promotes ATM activity through direct interactions with the MRN complex. Lee JH et al., 2010 Feb 3, EMBO JRead more
- Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Bartkova J et al., 2008 Dec, Mol OncolRead more
- Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Collaco RF et al., 2009 Sep 15, VirologyRead more
- An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. E X et al., 2011 May, PLoS PathogRead more
- Ancient and recent adaptive evolution of primate non-homologous end joining genes. Demogines A et al., 2010 Oct 21, PLoS GenetRead more
- Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. Mandriota SJ et al., 2010 Apr 23, J Biol ChemRead more
- Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. Lee JH et al., 2013 May 3, J Biol ChemRead more
- BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation. Wei F et al., 2015 Jun 4, OncogeneRead more
- Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein. Krueger L et al., 2007 Jan, CarcinogenesisRead more
- Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome. Lins S et al., 2009 Nov 1, GeneRead more