GTX30125 WB Image
GTX30125 WB Image
NBS1 antibody
GTX30125
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHamster, Human, Mouse, Primate
Overview
- SupplierGeneTex
- Product NameNBS1 antibody
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostRabbit
- IsotypeIgG
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq]
- ReactivityHamster, Human, Mouse, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Blooms syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto A et al., 2002 Apr 1, J Cell BiolRead more
- BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Ge C et al., 2015 Mar 17, Proc Natl Acad Sci U S ARead more
- Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Harfst E et al., 2000 Oct, Mol ImmunolRead more
- The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. Ge C et al., 2015, PLoS OneRead more