Overview
- SupplierGeneTex
- Product Namep21 Cip1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Novel Dnmt3a1 Transcript Inhibits Adipogenesis. Abdalla BA et al., 2018, Front PhysiolRead more
- A Novel DNA Methyltransferase Dnmt3a3 Splice Variant Represses Preadipocyte Proliferation and Differentiation. Abdalla BA et al., 2020, Front GenetRead more
- CARP, a myostatin-downregulated gene in CFM Cells, is a novel essential positive regulator of myogenesis. Ma G et al., 2014, Int J Biol SciRead more
- Control of preadipocyte proliferation, apoptosis and early adipogenesis by the forkhead transcription factor FoxO6. Abdalla BA et al., 2021 Jan 15, Life SciRead more
- MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cai B et al., 2018 Mar 6, Cell Death DisRead more
- Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Lee WY et al., 2015 Sep 29, OncotargetRead more