PDGF-BB antibody

GeneTex

PDGF-BB antibody

10

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Polyclonal

Goat

IgG

Platelet-Derived Growth Factor (PDGF) in serum is the principal mitogen present for cells of mesenchymal origin. PDGF is localized in alpha-granules of platelets and released during clot formation. PDGF from human platelets has been purified and described as a cationic glycoprotein (pI 9.5 to 10.4) having a molecular weight of approximately 30 kD and composed of two covalently linked subunits, designated as chains A (16 kD) and B (14 kD). In platelets, approximately 70% of the PDGF is present as the AB dimer, with most of the remainder as BB.Purified human PDGF shows substantial size heterogeneity, ranging from 27 to 31 kD, probably due to the presence of isoforms, glycosylation processing, aging of the platelets, and partial proteolysis during purification. The A and B chains are 40% homologous in sequence and are encoded by distinctly different genes. Each chain contains 8 cysteine residues, which are involved in intra- and inter-chain disulfide bonds. Cleavage of these bonds by reduction causes irreversible loss of biological activity. PDGF elicits multifunctional actions with a variety of cells.

Human

2°C to 8°C,-20°C

12352203