Phosphotyrosine antibody, MAb (ATTO-390)
ORB147694
ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityAll Species
Overview
- SupplierBiorbyt
- Product NamePhosphotyrosine antibody, MAb (ATTO-390)
- Delivery Days Customer10
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- Applications SupplierWB (1:1000), IHC (1:100) ICC, IP, WB, IHC
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDG104
- Concentration1 mg/ml
- ConjugateAtto 390
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMouse monoclonal to Phosphotyrosine (ATTO-390). Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a proteins activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (4-6). In particular, the phosphorylation of tyrosine is considered one of the key steps in signal transduction and regulation of enzymatic activity. Phosphotyrosine can be detected through specific antibodies, and are helpful in facilitating the identification of tyrosine kinase substrates..
- ReactivityAll Species
- Storage Instruction2°C to 8°C
- UNSPSC12352203