PIAS1 antibody, MAb

Biorbyt

PIAS1 antibody, MAb

16

Western Blot

WB:1:1000-1:5000 WB

Research Use Only

Monoclonal

2D7

Unconjugated

Mouse

IgG1

Mouse monoclonal to PIAS1.PIAS1 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator oftranscription)] family of transcriptional modulators. PIAS1 functions as an E3 small ubiquitin-likemodifier (SUMO) ligase. It stabilizes the interaction between UBE2I and the substrate, and functionsas a SUMO-tethering factor. PIAS1 plays an important role in the transcriptional regulation ofnumerous cellular pathways, including STAT, NF-B, p53 and the steroid hormone signalingpathways. Recent studies revealed that PIAS1 is an important regulator for innate immunity,inflammatory cytokine signaling and regulatory T cell differentiation.

2°C to 8°C,-20°C

12352203