PIK3R2 antibody, PAb

Biorbyt

PIK3R2 antibody, PAb

16

Western Blot, ImmunoHistoChemistry

Western blot - 0.1-0.5 μg/ml - Human, Mouse, Rat - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human, Rat - Mouse - By Heat WB, IHC

Research Use Only

Polyclonal

500 ug/ml

Rabbit

IgG

Rabbit Polyclonal to PIK3R2. PIK3R2(Phosphatidylinositol 3-kinase, regulatory subunit 2), also called p85-Beta, is an enzyme that in humans is encoded by the PIK3R2 gene. The PIK3R2 gene is mapped on 19p13.11. The NS1 protein from various influenza strains also bound p85-beta, but not p85-alpha. Binding of p85-beta and activation of PI3K required tyr89 of NS1, and mutant viruses expressing NS1 with a tyr89-to-phe substitution grew more slowly in cell culture than wildtype viruses. Using mouse embryonic fibroblasts, Park et al. showed that, in addition to regulating PI3K function, p85-alpha and p85-beta regulated the function of Xbp1s, a transcription factor that orchestrates the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress. Overexpression of PIK3R2 in livers of ob/ob mice increased glucose tolerance and reduced blood glucose concentrations.

Hamster, Human, Mouse, Rat

2°C to 8°C,-20°C

12352203