GTX83886 IHC-P Image
PIM2 antibody [10A12] - Overexpression Validated
GTX83886
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Human, Monkey, Rat
Overview
- SupplierGeneTex
- Product NamePIM2 antibody [10A12] - Overexpression Validated
- Delivery Days Customer10
- ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID10A12
- Concentration0.84 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionPromotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade - this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
- ReactivityCanine, Human, Monkey, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203