GTX102128 ICC/IF Image
GTX102128 ICC/IF Image
POM121 antibody [N2N3]
GTX102128
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePOM121 antibody [N2N3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.16 mg/ml
- IsotypeIgG
- Scientific DescriptionThe nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin. Schwartz M et al., 2015, NucleusRead more
- Evolution of a transcriptional regulator from a transmembrane nucleoporin. Franks TM et al., 2016 May 15, Genes DevRead more
- Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes. Hoffman LM et al., 2020 Jul 21, Mol Biol CellRead more
- Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Rodriguez-Bravo V et al., 2018 Aug 23, CellRead more
- POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. Ma H et al., 2019, J CancerRead more
- Proaggregant nuclear factor(s) trigger rapid formation of alpha-synuclein aggregates in apoptotic neurons. Jiang P et al., 2016 Jul, Acta NeuropatholRead more
- Spatial control of nucleoporin condensation by fragile X-related proteins. Agote-Aran A et al., 2020 Oct 15, EMBO JRead more
- The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Chow KH et al., 2014 Jan, Mol Biol CellRead more
- Tpr regulates the total number of nuclear pore complexes per cell nucleus. McCloskey A et al., 2018 Oct 1, Genes DevRead more