PUMA antibody [C2C3], C-term
GTX109675
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePUMA antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Wei RJ et al., 2016 Nov 15, Toxicol Appl PharmacolRead more
- FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-kappaB/Slug-mediated PUMA reduction. Wu DW et al., 2015 May 7, OncogeneRead more
- NF-kappaB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance. Chiu CF et al., 2016 May 3, Proc Natl Acad Sci U S ARead more
- Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. Chen MF et al., 2016 Jul 26, BMC CancerRead more