GTX111074 ICC/IF Image
GTX111074 ICC/IF Image
RIP antibody
GTX111074
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameRIP antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionEssential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via Lys-63-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C et al., 2021 Jan, Prog NeurobiolRead more
- DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells. Tsui KH et al., 2017 Aug, ReproductionRead more
- Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells. Lin CY et al., 2016, Cell Death DiscovRead more
- Subendothelial matrix components influence endothelial cell apoptosis in vitro. Saemisch M et al., 2019 Feb 1, Am J Physiol Cell PhysiolRead more
- Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo. Chen YH et al., 2020, Cancer Manag ResRead more
- Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Li CJ et al., 2015 Apr 24, Sci RepRead more