GTX113266 IHC-P Image
ROCK1 antibody [N1N2], N-term
GTX113266
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameROCK1 antibody [N1N2], N-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.89 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2. Kroiss A et al., 2015 May 28, OncogeneRead more
- Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Tsuchiya M et al., 2018 May 24, Nat CommunRead more
- Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes. Yahiro K et al., 2019 Aug, Cell MicrobiolRead more
- Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia. Jung HJ et al., 2019 Nov, Anticancer ResRead more
- Estrogen-related receptor alpha decreases RHOA stability to induce orientated cell migration. Sailland J et al., 2014 Oct 21, Proc Natl Acad Sci U S ARead more
- Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor. Yamada S et al., 2021 Jan-Dec, J Tissue EngRead more
- Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer. Steurer S et al., 2019 Sep 25, Aging (Albany NY)Read more