Overview
- SupplierGeneTex
- Product NameRPS6 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration2.34 mg/ml
- IsotypeIgG
- Scientific DescriptionRibosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. Goodson WH 3rd et al., 2011 Nov, CarcinogenesisRead more
- Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Chen CH et al., 2014 Aug 15, OncotargetRead more
- Rhapontigenin inhibits TGF-beta-mediated epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1alpha degradation. Yeh YH et al., 2016 May, Oncol RepRead more