GTX110593 IHC-P Image
GTX110593 IHC-P Image
SP1 antibody
GTX110593
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameSP1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.55 mg/ml
- IsotypeIgG
- Scientific DescriptionTranscription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Cellular density-dependent increases in HIF-1alpha compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Seira N et al., 2018 Dec, Pharmacol Res PerspectRead more
- Noggin Inhibits IL-1beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis. Chien SY et al., 2020 Apr 10, CellsRead more
- Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Carrasco-Torres G et al., 2017, Oxid Med Cell LongevRead more
- ZEB1 Mediates Fibrosis in Corneal Endothelial Mesenchymal Transition Through SP1 and SP3. Lee J et al., 2020 Jul 1, Invest Ophthalmol Vis SciRead more