GTX133464 WB Image
GTX133464 WB Image
STAT3 (phospho Tyr705) antibody
GTX133464
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameSTAT3 (phospho Tyr705) antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.66 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling. Fan JJ et al., 2019 Nov 15, Antioxidants (Basel)Read more
- Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway. Shen M et al., 2019 Apr 8, J Exp Clin Cancer ResRead more
- Inhibition of miR-221 influences bladder cancer cell proliferation and apoptosis. Liu H et al., 2017 Jul, Eur Rev Med Pharmacol SciRead more
- Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells. Li X et al., 2017 Dec, Biomed PharmacotherRead more