GTX48721 IP Image
GRASP antibody - KO/KD, Overexpression Validated
GTX48721
ApplicationsImmunoPrecipitation, Western Blot, ELISA
Product group Antibodies
ReactivityMouse
Overview
- SupplierGeneTex
- Product NameGRASP antibody - KO/KD, Overexpression Validated
- Delivery Days Customer10
- ApplicationsImmunoPrecipitation, Western Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.03 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionTamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs). The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.
- ReactivityMouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203