GTX107505 IHC-P Image
GTX107505 IHC-P Image
TIE2 antibody
GTX107505
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameTIE2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.43 mg/ml
- IsotypeIgG
- Scientific DescriptionThe TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A collagen IV-derived peptide disrupts alpha5beta1 integrin and potentiates Ang2/Tie2 signaling. Mirando AC et al., 2019 Feb 21, JCI InsightRead more
- Osteopontin-integrin engagement induces HIF-1alpha-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. Fan CS et al., 2018 Jan 12, OncotargetRead more