TIM-1 antibody - KO/KD Validated

GeneTex

TIM-1 antibody - KO/KD Validated

10

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Rabbit

IgG

The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

Human, Mouse, Rat

2°C to 8°C,-20°C

12352203