TLR4 antibody

Biorbyt

TLR4 antibody

16

WB: 1:500-2000 WB

Research Use Only

IgG

Rabbit polyclonal antibody to TLR4. The protein encoded by this gene is a member of the Tolllike receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogenassociated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gramnegative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

-20°C

12352203