Trkct1 antibody - KO/KD, Overexpression Validated

GeneTex

Trkct1 antibody - KO/KD, Overexpression Validated

10

ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Rabbit

IgG

TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform. TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6-Rac1 signaling pathway (Esteban et al., 2006).

Human, Mouse, Rat

2°C to 8°C,-20°C

12352203