GTX108058 ICC/IF Image
GTX108058 ICC/IF Image
VPS35 antibody [C3], C-term
GTX108058
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameVPS35 antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.66 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N. Rahman AA et al., 2020 Aug 10, NeuroscienceRead more
- Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting. Lenoir M et al., 2018 Mar 8, Nat CommunRead more
- Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. Succoio M et al., 2015 Oct 14, J ProteomicsRead more
- The Parkinsons Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. Beilina A et al., 2020 May 5, Cell RepRead more
- VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinsons disease. Miura E et al., 2014 Nov, Neurobiol DisRead more