Overview
- SupplierGeneTex
- Product NameWip1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.5 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- IL-1beta Inflammatory Cytokine-Induced TP63 Isoform deltaNP63alpha Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. Mendoza-Rodriguez MG et al., 2019 Jan 11, Int J Mol SciRead more