YBX1 antibody, PAb
ORB76271
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat
Overview
- SupplierBiorbyt
- Product NameYBX1 antibody, PAb
- Delivery Days Customer16
- ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry
- Applications SupplierWestern blot - 0.1-0.5 μg/ml - Human, Mouse, Rat - - - Immunohistochemistry(Paraffin-embedded Section) - 2-5 μg/ml - Human, Mouse, Rat - - - Flow Cytometry - 1-3 μg/1x10^6 cells - Human - - - FC, WB, IHC
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration500 ug/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit Polyclonal to YBX1. YBX1(Y box binding protein 1), commonly referred to as YB-1 by researchers, is a human protein. YB1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414 and contains 18% basic residues and putative nuclear localization signals. The YBX1 gene is mapped on 1p34.2. Ybx1 was highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML), a hematopoietic precursor cell line, but that it was downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. Ybx1 was expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of YBX1 in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant YBX1 expression in leukemic cells may contribute to leukemia development by blocking differentiation.
- ReactivityHamster, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203