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ABL (T315I) Assay Kit

Research Use Only
79576
BPS Bioscience
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    ABL (T315I) Assay Kit
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    The Abelson (ABL) family of nonreceptor tyrosine kinases is critical to the progression and treatment of chronic myeloid leukemia (CML). The single-point mutation T315I has been linked to drug resistance and poor prognosis, making it an important drug target. The ABL (T315I) Assay Kit is designed to measure ABL activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The ABL (T315I) Assay Kit comes in a convenient 96-well format, with enough purified recombinant ABL enzyme, ABLtide peptide, ATP, and kinase assay buffer for 100 enzyme reactions.
  • UNSPSC
    41116133

References

  • Greuber, E. K., Smith-Pearson, P., Wang, J., & Pendergast, A. M. (2013). Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors. Nature Reviews. Cancer, 13(8), 559-571
  • Ganguly SS, Plattner R. (2012). Activation of Abl Family Kinases in Solid Tumors. Genes & Cancer 3(5-6):414-425