Leptin Mouse/Rat ELISA

Catalog number: RD291001200R
Brand: BioVendor
Packing: 96 wells
Price: € 330.00
Expected delivery time: 7 days

Product specifications for - Leptin Mouse/Rat ELISA

Product group: Assays
Category: ELISA / EIA
Molecular weight: 16 kDa
Assay Precision: Inter assay: n = 8, CV = 3,4%, Intra assay: n = 8, CV = 2,2%,
Assay Sample Type: total serum
Assay Time: The total assay time is less than four hours.
Assay Detection Range: 100 - 4000 pg/ml
  Research Use Only
UNSPSC: 41116158
Storage instructions: Store the kit at 2-8-¦C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Scientific information: 
Scientific info: Leptin is a protein hormone with important effects in metabolism and regulating body weight. It is a single-chain 16 kDa protein consisting of 146 amino acid residues and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, small amounts of leptin are also secreted by cells in the epithelium of stomach and in the placenta. Leptin s effect on body weight is mediated through effects on hypothalamic centers, where leptin receptors are highly expressed. Leptin has a dual action, it decreases the appetite and increases energy consumption. A mutations in the ob gene of leptin or in the gene of leptin receptor causes hyperphagia, reduced energy expenditure, and severe obesity in the ob/ob mice. Ob gene knockout mice are also characterized by several metabolic abnormalities including hyperglucocorticoidemia, hyperglycaemia, hyperinsulinemia and insulin resistance. When ob/ob mice are treated with injections of leptin, they lose their excess fat and return to normal body weight. Studies have shown that leptin appears to be a significant regulator of reproductive function. In addition, leptin is involved in bone metabolism and plays a significant role as an immunomodulator.
Additional information: 
Synonyms: RD291001200R; BioVendor
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