Nampt (Visfatin/PBEF) (human) (IntraCellular) ELISA Kit

Catalog number: AG-45A-0008YEK-KI01
Brand: AdipoGen Life Sciences
Packing: 96 wells
Price: € 680.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Nampt (Visfatin/PBEF) (human) (IntraCellular) ELISA Kit

Overview: 
Product group: Assays
Category: ELISA / EIA
Application: ELISA
Species: Human
Target: NAMPT
Target description: nicotinamide phosphoribosyltransferase
Properties: 
Assay Sensitivity: 30pg/ml
Assay Detection Range: 0.25 to 16ng/ml
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: ELISA Assay. Detects human Nampt. Weakly cross-reacts (<15%) with mouse Nampt and rat Nampt. Does not cross-react with human adiponectin, human resistin, human RELM-beta or human leptin. Colorimetric assay. Sample Types: Cell Lysate. Range: 0.25 to 16ng/ml. Sensitivity: 30pg/ml. Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDA adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. It has been shown that Nampt expression is increased in different diseases, like diabetes, obesity, fetal growth retardation, sepsis, inflammatory bowel disease, Crohns disease and rheumatoid arthritis. Furthermore, Nampt might be a marker of pre-eclampsia and of endothelial health. - Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDA adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. It has been shown that Nampt expression is increased in different diseases, like diabetes, obesity, fetal growth retardation, sepsis, inflammatory bowel disease, Crohns disease and rheumatoid arthritis. Furthermore, Nampt might be a marker of pre-eclampsia and of endothelial health.
Gene ID: 10135
Swiss prot ID: P43490
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-45A-0008YEK-KI01; AdipoGen Life Sciences; 1110035O14Rik; NAmPRTase; nicotinamide phosphoribosyltransferase; PBEF; PBEF1; pre-B cell-enhancing factor; pre-B-cell colony-enhancing factor 1; VF; VISFATIN
Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes: A. Garten, et al.; BBRC 391, 376 (2010) Read more
Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans: D. Friebe, et al.; Diabetologia 54, 1200 (2011) Read more
Visceral adipose tissue visfatin in nonalcoholic fatty liver disease: R. Gaddipati, et al.; Ann. Hepatol. 9, 266 (2010) Read more
In vivo Suppression of Visfatin by Oral Glucose Uptake: Evidence for a Novel Incretin-Like Effect by Glucagon-Like Peptide-1 (GLP-1): M. Bala, et al.; J. Clin. Endocrinol. Metab. 96, 2493 (2011) Read more