Resistin Human ELISA

Catalog number: RD191016100
Brand: BioVendor
Packing: 96 wells
Price: € 407.00
Expected delivery time: 7 days

Product specifications for - Resistin Human ELISA

Product group: Assays
Category: ELISA / EIA
Assay Sensitivity: 0,012 ng/ml
Assay Precision: Inter assay: n = 5, CV = 7,6%, Intra assay: n = 8, CV = 5,9%,
Assay Sample Type: serum and plasma (EDTA, citrate, heparin)
Assay Time: The total assay time is less than 4 hours
Assay Detection Range: 1 - 50 ng/ml
  IVD Certification
UNSPSC: 41116158
Storage instructions: Store the kit at 2-8-¦C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Scientific information: 
Scientific info: Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteinerich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) or FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrophobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26. Much of the early investigations about the resistin molecule are based on the mouse model. Resistin, produced and secreted primarily by adipocytes in mice, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. Compared to the mouse model, human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression. On the other hand, resistin was found to be expressed at high levels in human monocytes, macrophages and bone marrow. Recent investigations have shown that human resistin is correlated with metabolic syndrome and obesity-related disorders. Malo et al. have reported that resistin levels are positively associated with waist circumference, tumor necrosis factor-a, and insulin resistance assessed by the homeostasis model, and inversely correlated with total cholesterol, HDL cholesterol, and LDL cholesterol. Moreover, Sadhasiv et al. found a positive correlation of SAT (subcutaneous adipose tissue) resistin mRNA expression with serum resistin, BMI and insulin resistance (HOMA index). Based on the above reports human resistin might be an important marker that acts as the link between obesity and insulin resistance. Resistin can play a role also in inflammation processes and in atherosclerosis. Clinical use and areas of investigation: Energy metabolism and body weight regulation, Metabolic syndrome, Inflammation, Atherosclerosis
Additional information: 
Synonyms: RD191016100; BioVendor
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