Bicuculline [485-49-4]

MedChem Express

Bicuculline [485-49-4]

10

485-49-4

Research Use Only

98%

C20H17NO6

367.35

Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 microM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) .

O=C1O[C@@H]([C@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=CC=C(OCO6)C6=C51

2°C to 8°C,-20°C,-80°C

12352200