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ProductsBack/1-Azakenpaullone [676596-65-9]
Chemical Structure
Chemical Structure
Chemical Structure

1-Azakenpaullone [676596-65-9]

Research Use Only
AG-CR1-0035
AdipoGen Life Sciences
CAS Number676596-65-9
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Product group Chemicals
Estimated Purity>98% (HPLC, NMR)
Molecular Weight328.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    1-Azakenpaullone [676596-65-9]
  • Delivery Days Customer
    10
  • CAS Number
    676596-65-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (HPLC, NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C15H10BrN3O
  • Molecular Weight
    328.2
  • Scientific Description
    Chemical. CAS: 676596-65-9. Formula: C15H10BrN3O. MW: 328.2. Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM). - Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM) [1, 2].
  • SMILES
    BrC1=CC2=C(NC3=C2CC(=O)NC2=C3N=CC=C2)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett.14, 413 (2004)
  • Studying the mechanism that enables paullones to selectively inhibit glycogen synthase kinase 3 rather than cyclin-dependent kinase 5 by molecular dynamics simulations and free-energy calculations: Q. Chen, et al.; J. Mol. Model. 17, 795 (2011)