A-366 [1527503-11-2]
HY-12583
Overview
- SupplierMedChem Express
- Product NameA-366 [1527503-11-2]
- Delivery Days Customer10
- CAS Number1527503-11-2
- CertificationResearch Use Only
- Estimated Purity98%
- Molecular FormulaC19H27N3O2
- Molecular Weight329.44
- Scientific DescriptionA-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families.
- SMILESCOC1=CC2=C(N=C(N)C23CCC3)C=C1OCCCN4CCCC4
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200