A-366 [1527503-11-2]

MedChem Express

A-366 [1527503-11-2]

10

1527503-11-2

Research Use Only

98%

C19H27N3O2

329.44

A-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families.

COC1=CC2=C(N=C(N)C23CCC3)C=C1OCCCN4CCCC4

2°C to 8°C,-20°C,-80°C

12352200