Acalabrutinib (ACP-196) [1420477-60-6]

Selleck Chemicals

Acalabrutinib (ACP-196) [1420477-60-6]

9

1420477-60-6

Research Use Only

Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.

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