AX-024 [1370544-73-2]

MedChem Express

AX-024 [1370544-73-2]

10

1370544-73-2

Research Use Only

98%

C21H22FNO2

339.4

AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-alpha, IFN-gamma, IL-10 and IL-17A.

COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1

2°C to 8°C,-20°C,-80°C

12352200