BAY 11-7082 [19542-67-7]

Catalog number: AG-CR1-0013-M010
Brand: AdipoGen Life Sciences
Packing: 10 mg
Other sizes: 50 mg
Price: € 70.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - BAY 11-7082 [19542-67-7]

Product group: Chemicals
Category: Other
CAS No.: 19542-67-7
Purity: >99% (NMR)
Molecular Formula: C10H9NO2S
Molecular weight: 207.3
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. NLRP3 inflammasome inhibitor. Reduces ATPase activity of the NLRP3 inflammasome. Inhibits platelet aggregation.
Safety information: 
Additional information: 
Synonyms: AG-CR1-0013-M010; AdipoGen Life Sciences; (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) Read more
Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells: N. Mori, et al.; Blood 100, 1828 (2002) Read more
Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro: M. Lappas et al.; Endocrinology 146, 1491 (2005) Read more
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome: C. Juliana, et al.; J. Biol. Chem. 285, 9792 (2010) Read more
A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations: H.S. Lee, et al.; Eur. J. Pharmacol. 627, 85 (2010) Read more