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Chemical Structure
Chemical Structure
Chemical Structure

C646 [328968-36-1]

Research Use Only
AG-CR1-3508
AdipoGen Life Sciences
CAS Number328968-36-1
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Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight445.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    C646 [328968-36-1]
  • Delivery Days Customer
    10
  • CAS Number
    328968-36-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C24H19N3O6
  • Molecular Weight
    445.4
  • Scientific Description
    Chemical. CAS: 328968-36-1. Formula: C24H19N3O6. MW: 445.4. Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines. - Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.
  • SMILES
    CC1=NN(C(=O)\C1=C\C1=CC=C(O1)C1=CC(C)=C(C)C=C1[N+]([O-])=O)C1=CC=C(C=C1)C(O)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor: E.M. Bowers, et al.; Chem. Biol. 17, 471 (2010)
  • HAT Trick: p300, Small Molecule, Inhibitor: M. Ott & E. Verdin; Chem. Biol. 17, 417 (2010)
  • Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetics remodeling and the expression of pluripotency-associated genes: P. Mali, et al.; Stem Cells 28, 713 (2010)
  • Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP: N.T. Crump, et al.; PNAS 108, 7814 (2011)
  • Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300: R. Marek, et al.; J. Neurosci. 31, 7486 (2011)
  • Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines: F.R. Santer, et al.; Mol. Cancer Ther. 10, 1644 (2011)