More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/CK2 Inhibitor 10 [1361229-76-6]
Chemical Structure
Chemical Structure
Chemical Structure

CK2 Inhibitor 10 [1361229-76-6]

Research Use Only
AG-CR1-3626
AdipoGen Life Sciences
Estimated Purity>98% (HPLC, MS, NMR)
DownloadDatasheet
DownloadMSDS
Product group Chemicals
Molecular Weight354.4 . 9.0
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    CK2 Inhibitor 10 [1361229-76-6]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (HPLC, MS, NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C18H14N2O4S . 0.5H2O
  • Molecular Weight
    354.4 . 9.0
  • Scientific Description
    Chemical. CAS: 1361229-76-6. Formula: C18H14N2O4S . 0.5H2O. MW: 354.4 . 9.0. Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis. - Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
  • SMILES
    COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds: Z. Hou, et al.; J. Med. Chem. 55, 2899 (2012)
  • Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure: K. Shinoda, et al.; Cell Metab. 22, 997 (2015)