Crizotinib [877399-52-5]
HY-50878
CAS Number877399-52-5
Product group Chemicals
Estimated Purity97.42%
Molecular Weight450.34
Overview
- SupplierMedChem Express
- Product NameCrizotinib [877399-52-5]
- Delivery Days Customer10
- CAS Number877399-52-5
- CertificationResearch Use Only
- Estimated Purity97.42%
- Molecular FormulaC21H22Cl2FN5O
- Molecular Weight450.34
- Scientific DescriptionCrizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.
- SMILESClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200