Cyclosporin A [59865-13-3]

Catalog number: HY-B0579_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 10 mM
200 mg
500 mg
Price: € 89.00
Expected delivery time: 10 days
Cyclosporin A Chemical Structure
CAS No. : 59865-13-3...

Product specifications for - Cyclosporin A [59865-13-3]

Product group: Chemicals
Category: Other
CAS No.: 59865-13-3
Purity: >98%
Molecular Formula: C62H111N11O12
Molecular weight: 1202.61
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM. IC50 value: 7 nM Target: calcineurin Cyclosporin A is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells. Ciclosporin binds to the cytosolic protein cyclophilin of lymphocytes, especially T cells. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. Ciclosporin affects mitochondria by preventing the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. This is not the primary mechanism of action for clinical use, but is an important effect for research on apoptosis [1-3].
Safety information: 
Additional information: 
Synonyms: HY-B0579; Cyclosporine; Ciclosporin; MedChem Express
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Takahagi A, Shindo T, Chen-yoshikawa TF, et al. Trametinib Attenuates Delayed Rejection and Preserves Thymic Function in Rat Lung Transplantation. Am J Respir Cell Mol Biol. 2019;61(3):355-366. Read more
Bi S, Huang W, Chen S, et al. Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. Int J Biol Macromol. 2020;150:261-280. Read more
Zhang R, Li G, Zhang Q, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018;9(6):598. Read more
Stagni F, Salvalai ME, Giacomini A, et al. Neonatal treatment with cyclosporine A restores neurogenesis and spinogenesis in the Ts65Dn model of Down syndrome. Neurobiol Dis. 2019;129:44-55. Read more
Wei X, Li H, Zhang Y, et al. Ca-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immunity in an Early Vertebrate. J Immunol. 2020;204(3):569-585. Read more