Epiberberine chloride [889665-86-5]

MedChem Express

Epiberberine chloride [889665-86-5]

10

889665-86-5

99.02%

C20H18ClNO4

371.81

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 microM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 microM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKalpha/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease.

COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-]

2°C to 8°C,-20°C,-80°C

12352200