INCB 024360 [1204669-58-8]

Catalog number: HY-15689_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: Also available in other sizes.
Price: € 250.20 € 278.00
Expected delivery time: 10 days
Quantity:

Product specifications for - INCB 024360 [1204669-58-8]

Overview: 
Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 1204669-58-8
Properties: 
Purity: >98%
Molecular Formula: C11H13BrFN7O4S
Molecular weight: 438.2328
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value <100 nM. IC50 Value: <100 nM [1] Target: Indoleamine-2,3-dioxygenase IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: HY-15689; Epacadostat
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor', Moyer BJ. Toxicol Appl Pharmacol. 2017 May 15;323:74-80. Read more