MKC8866 [1338934-59-0]
HY-104040
CAS Number1338934-59-0
Product group Chemicals
Estimated Purity98.22%
Molecular Weight361.35
Overview
- SupplierMedChem Express
- Product NameMKC8866 [1338934-59-0]
- Delivery Days Customer10
- CAS Number1338934-59-0
- Estimated Purity98.22%
- Molecular FormulaC18H19NO7
- Molecular Weight361.35
- Scientific DescriptionMKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 microM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 microM and unstresses RPMI 8226 cells with an IC50 of 0.14 microM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.
- SMILESO=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200