L-685458 [292632-98-5]
HY-19369
CAS Number292632-98-5
Product group Chemicals
Estimated Purity99.33%
Molecular Weight672.85
Overview
- SupplierMedChem Express
- Product NameL-685458 [292632-98-5]
- Delivery Days Customer10
- CAS Number292632-98-5
- Estimated Purity99.33%
- Molecular FormulaC39H52N4O6
- Molecular Weight672.85
- Scientific DescriptionL-685458 is a potent transition state analog (TSA) gamma-secretase inhibitor (GSI). L-685458 inhibits amyloid beta-protein precursor gamma-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits gamma-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimers disease (AD) and cancers.
- SMILESO=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200