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ProductsBack/LDN-193189 [1062368-24-4]

LDN-193189 [1062368-24-4]

Research Use Only

S2618

CAS Number1062368-24-4

DownloadDatasheet

Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
LDN-193189 [1062368-24-4]
Delivery Days Customer
9
CAS Number
1062368-24-4
Certification
Research Use Only
Scientific Description
LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-bèta. For animal testing, the water-soluble S7507 LDN-193189 2HCl is recommended.
UNSPSC
12352200