Mitoxantrone [65271-80-9]

MedChem Express

Mitoxantrone [65271-80-9]

10

65271-80-9

98%

C22H28N4O6

444.48

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 microM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively.

O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O

-20°C,-80°C

12352200