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ProductsBack/MMG-0358 [1378976-02-3]
Chemical Structure
Chemical Structure
Chemical Structure

MMG-0358 [1378976-02-3]

Research Use Only
AG-CR1-3630
AdipoGen Life Sciences
CAS Number1378976-02-3
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Product group Chemicals
Estimated Purity>98%
Molecular Weight195.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    MMG-0358 [1378976-02-3]
  • Delivery Days Customer
    10
  • CAS Number
    1378976-02-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C8H6ClN3O
  • Molecular Weight
    195.6
  • Scientific Description
    Chemical. CAS: 1378976-02-3. Formula: C8H6ClN3O. MW: 195.6. Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo. - Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
  • SMILES
    OC1=C(C=C(Cl)C=C1)C1=CN=NN1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)
  • Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)